|Other Names||Leucine-rich repeat flightless-interacting protein 2, LRR FLII-interacting protein 2, LRRFIP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.|
|Tissue Location||Widely expressed, with highest levels in heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
LRRF2 may function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.
Dai, P., et al. J. Immunol. 182(6):3450-3460(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Liu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 102(6):1927-1932(2005)
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