|Other Names||Leucine-rich repeat flightless-interacting protein 2, LRR FLII-interacting protein 2, LRRFIP2|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.|
|Tissue Location||Widely expressed, with highest levels in heart and skeletal muscle.|
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LRRF2 may function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.
Dai, P., et al. J. Immunol. 182(6):3450-3460(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Liu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 102(6):1927-1932(2005)
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