|Other Names||Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR, LGR3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in the thyroid.|
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Provided below are standard protocols that you may find useful for product applications.
TSHR is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism.
Sun, S.C., et al. J. Biol. Chem. 285(6):3758-3765(2010)Liu, C., et al. Ann. Otol. Rhinol. Laryngol. 119(2):118-124(2010)Atzmon, G., et al. J. Clin. Endocrinol. Metab. 94(12):4768-4775(2009)
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