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NR3C1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P04150
Peptide ID 44175
Additional Information
Gene ID 2908
Other Names Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR3C1
Synonyms GRL
Function Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.
Cellular Location Cytoplasm. Mitochondrion. Nucleus Note=Cytoplasmic in the absence of ligand, nuclear after ligand- binding
Tissue Location Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
Research Areas
Citations (0)

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NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance.


Geelhoed, M.J., et al. BMC Med. Genet. 11, 39 (2010) Szilagyi, K., et al. Neuro Endocrinol. Lett. 30(5):629-636(2009)Tian, S., et al. Biochem. J. 367 (PT 3), 907-911 (2002) Itoh, M., et al. Mol. Endocrinol. 16(10):2382-2392(2002)Wang, Z., et al. J. Biol. Chem. 277(29):26573-26580(2002)

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$ 80.00
Cat# BP4867b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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