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MOCOS Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96EN8 |
|---|
| Gene ID | 55034 |
|---|---|
| Other Names | Molybdenum cofactor sulfurase {ECO:0000255|HAMAP-Rule:MF_03050}, MCS {ECO:0000255|HAMAP-Rule:MF_03050}, MOS {ECO:0000255|HAMAP-Rule:MF_03050}, MoCo sulfurase {ECO:0000255|HAMAP-Rule:MF_03050}, hMCS, 2819 {ECO:0000255|HAMAP-Rule:MF_03050}, Molybdenum cofactor sulfurtransferase {ECO:0000255|HAMAP-Rule:MF_03050}, MOCOS {ECO:0000255|HAMAP-Rule:MF_03050} |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MOCOS {ECO:0000255|HAMAP-Rule:MF_03050} |
|---|---|
| Function | Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1; MIM 602841), which is required for their enzymatic activities.
References
Smith, M.A., et al. Aliment. Pharmacol. Ther. 30(4):375-384(2009)Peretz, H., et al. Mol. Genet. Metab. 91(1):23-29(2007)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
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