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GSDMA Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96QA5
Peptide ID 91113233
Additional Information
Gene ID 284110
Other Names Gasdermin-A, Gasdermin-1, GSDMA, GSDM, GSDM1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSDMA
Synonyms GSDM, GSDM1
Function May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).
Cellular Location Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P57764}. Cell membrane {ECO:0000250|UniProtKB:P57764}
Tissue Location Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium. Down-regulateded in gastric cancer cells
Research Areas
Citations (0)

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Background

GSDMA induces apoptosis.

References

Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)Saeki, N., et al. Genes Chromosomes Cancer 48(3):261-271(2009)Tamura, M., et al. Genomics 89(5):618-629(2007)

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$ 80.00
Cat# BP4887a
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