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GSDMA Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96QA5
Additional Information
Gene ID 284110
Other Names Gasdermin-A, Gasdermin-1, GSDMA, GSDM, GSDM1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSDMA (HGNC:13311)
Function [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon infection by S.pyogenes, specifically cleaved by S.pyogenes effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N- terminal) that binds to membranes and forms pores, triggering pyroptosis.
Cellular Location [Gasdermin-A]: Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6}
Tissue Location Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium Down-regulated in gastric cancer cells.
Research Areas
Citations (0)
citation

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Background

GSDMA induces apoptosis.

References

Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)Saeki, N., et al. Genes Chromosomes Cancer 48(3):261-271(2009)Tamura, M., et al. Genomics 89(5):618-629(2007)

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$ 277.78
Cat# BP4887a
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