GSDMA Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96QA5 |
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Gene ID | 284110 |
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Other Names | Gasdermin-A, Gasdermin-1, GSDMA, GSDM, GSDM1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GSDMA (HGNC:13311) |
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Function | [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein and acts as a sensor of infection: upon infection by S.pyogenes, specifically cleaved by S.pyogenes effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N- terminal) that binds to membranes and forms pores, triggering pyroptosis. |
Cellular Location | [Gasdermin-A]: Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6} |
Tissue Location | Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium Down-regulated in gastric cancer cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GSDMA induces apoptosis.
References
Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)Saeki, N., et al. Genes Chromosomes Cancer 48(3):261-271(2009)Tamura, M., et al. Genomics 89(5):618-629(2007)
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