|Other Names||SH3KBP1-binding protein 1, SHKBP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.|
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Provided below are standard protocols that you may find useful for product applications.
Liu, J.P., et al. Mol. Cell. Biochem. 292 (1-2), 189-195 (2006) Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)Borinstein, S.C., et al. Cell. Signal. 12 (11-12), 769-779 (2000)
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