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S17A9 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BYT1 |
|---|
| Gene ID | 63910 |
|---|---|
| Other Names | Solute carrier family 17 member 9, SLC17A9, C20orf59 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC17A9 {ECO:0000303|PubMed:18375752, ECO:0000312|HGNC:HGNC:16192} |
|---|---|
| Function | Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles (PubMed:18375752, PubMed:23467297). By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles (PubMed:35269509). Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles (PubMed:18375752, PubMed:23467297). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:Q8VCL5}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Lysosome membrane {ECO:0000250|UniProtKB:Q8VCL5}; Multi- pass membrane protein. Note=Localizes to mucin granules and vesicles. |
| Tissue Location | Widely expressed, but more predominantly in adrenal gland, brain and thyroid. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
S17A9 involved in vesicular storage and exocytosis of ATP. S17A9 may accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles.
References
Sawada, K., et al. Proc. Natl. Acad. Sci. U.S.A. 105(15):5683-5686(2008)Jikuya, H., et al. DNA Res. 10(1):49-57(2003)Deloukas, P., et al. Nature 414(6866):865-871(2001)
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