GARNL4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q684P5 |
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Gene ID | 23108 |
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Other Names | Rap1 GTPase-activating protein 2, Rap1GAP2, GTPase-activating Rap/Ran-GAP domain-like protein 4, RAP1GAP2, GARNL4, KIAA1039, RAP1GA2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RAP1GAP2 |
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Synonyms | GARNL4, KIAA1039, RAP1GA2 |
Function | GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP- bound state. |
Cellular Location | Cytoplasm. Cytoplasm, perinuclear region |
Tissue Location | Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GARNL4 encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage.
References
Neumuller, O., et al. Blood 114(7):1396-1404(2009)Hoffmeister, M., et al. J. Biol. Chem. 283(4):2297-2306(2008)Schultess, J., et al. Blood 105(8):3185-3192(2005)
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