|Other Names||Rap1 GTPase-activating protein 2, Rap1GAP2, GTPase-activating Rap/Ran-GAP domain-like protein 4, RAP1GAP2, GARNL4, KIAA1039, RAP1GA2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||GARNL4, KIAA1039, RAP1GA2|
|Function||GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.|
|Cellular Location||Cytoplasm. Cytoplasm, perinuclear region|
|Tissue Location||Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
GARNL4 encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage.
Neumuller, O., et al. Blood 114(7):1396-1404(2009)Hoffmeister, M., et al. J. Biol. Chem. 283(4):2297-2306(2008)Schultess, J., et al. Blood 105(8):3185-3192(2005)
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