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GABRB1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P18505 |
|---|
| Gene ID | 2560 |
|---|---|
| Other Names | Gamma-aminobutyric acid receptor subunit beta-1, GABA(A) receptor subunit beta-1, GABRB1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GABRB1 |
|---|---|
| Function | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as a receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as a ligand-gated chloride channel. |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P50571}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P50571}. Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P50571} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor.
References
Craddock, N., et al. Mol. Psychiatry 15(2):146-153(2010)Hamshere, M.L., et al. Br J Psychiatry 195(1):23-29(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009)
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