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GLCE Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O94923
Additional Information
Gene ID 26035
Other Names D-glucuronyl C5-epimerase, Heparan sulfate C5-epimerase, Hsepi, Heparin/heparan sulfate:glucuronic acid C5-epimerase, Heparosan-N-sulfate-glucuronate 5-epimerase, GLCE, KIAA0836 {ECO:0000312|EMBL:BAA748591}
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLCE
Synonyms KIAA0836 {ECO:0000312|EMBL:BAA74859.1}
Function Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.
Cellular Location Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EPS3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9EPS3}
Research Areas
Citations (0)
citation

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Background

Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines.

References

Grigorieva, E., et al. Int. J. Cancer 122(5):1172-1176(2008)Ghiselli, G., et al. Biochem. J. 390 (PT 2), 493-499 (2005) Hagner-McWhirter, A., et al. J. Biol. Chem. 279(15):14631-14638(2004)

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$ 277.78
Cat# BP4927c
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