GLCE Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O94923 |
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Gene ID | 26035 |
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Other Names | D-glucuronyl C5-epimerase, Heparan sulfate C5-epimerase, Hsepi, Heparin/heparan sulfate:glucuronic acid C5-epimerase, Heparosan-N-sulfate-glucuronate 5-epimerase, GLCE, KIAA0836 {ECO:0000312|EMBL:BAA748591} |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GLCE |
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Synonyms | KIAA0836 {ECO:0000312|EMBL:BAA74859.1} |
Function | Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. |
Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EPS3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9EPS3} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines.
References
Grigorieva, E., et al. Int. J. Cancer 122(5):1172-1176(2008)Ghiselli, G., et al. Biochem. J. 390 (PT 2), 493-499 (2005) Hagner-McWhirter, A., et al. J. Biol. Chem. 279(15):14631-14638(2004)
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