|Other Names||Heparan-sulfate 6-O-sulfotransferase 1, HS6ST-1, 282-, HS6ST1, HS6ST|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in fetal brain.|
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Provided below are standard protocols that you may find useful for product applications.
HS6ST1 is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene.
Habuchi, H., et al. Biochem. J. 371 (PT 1), 131-142 (2003) Habuchi, H., et al. J. Biol. Chem. 273(15):9208-9213(1998)
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