|Other Names||B9 domain-containing protein 2, MKS1-related protein 2, B9D2, MKSR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.|
|Cellular Location||Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
B9D2 encodes a B9 domain protein, which are exclusively found in ciliated organisms. The gene is upregulated during mucociliary differentiation, and the encoded protein localizes to basal bodies and cilia. Disrupting expression of this gene results in ciliogenesis defects.
Bialas, N.J., et al. J. Cell. Sci. 122 (PT 5), 611-624 (2009) Town, T., et al. Proc. Natl. Acad. Sci. U.S.A. 105(8):2853-2858(2008)Ponsard, C., et al. Front. Biosci. 12, 1661-1669 (2007)
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