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KCNG3 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TAE7 |
|---|
| Gene ID | 170850 |
|---|---|
| Other Names | Potassium voltage-gated channel subfamily G member 3, Voltage-gated potassium channel subunit Kv101, Voltage-gated potassium channel subunit Kv63, KCNG3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KCNG3 |
|---|---|
| Function | Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage- gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745). Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:19074135). Remains intracellular in the absence of KCNB1 (PubMed:12060745). |
| Tissue Location | Expressed in the brain, liver, testis, small intestine, colon, thymus and adrenal gland (PubMed:11852086, PubMed:12060745). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule.
References
Mederos Y Schnitzler, M., et al. J. Biol. Chem. 284(7):4695-4704(2009)Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)Vega-Saenz de Miera, E.C. Brain Res. Mol. Brain Res. 123 (1-2), 91-103 (2004)
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