|Other Names||Ras-related GTP-binding protein D, Rag D, RagD, RRAGD (HGNC:19903)|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.|
|Cellular Location||Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA|
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Provided below are standard protocols that you may find useful for product applications.
RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.
Olsen, J.V., et al. Cell 127(3):635-648(2006)de Wit, N.J., et al. Br. J. Cancer 92(12):2249-2261(2005)Sekiguchi, T., et al. J. Biol. Chem. 279(9):8343-8350(2004)
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