LPPR4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q7Z2D5 |
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Other Accession | NP_055654 |
Gene ID | 9890 |
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Other Names | Lipid phosphate phosphatase-related protein type 4, Brain-specific phosphatidic acid phosphatase-like protein 1, Plasticity-related gene 1 protein, PRG-1, LPPR4, KIAA0455, PRG1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PLPPR4 (HGNC:23496) |
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Function | Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane (By similarity). Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid- induced axon collapse (By similarity). |
Cellular Location | Postsynaptic density membrane; Multi-pass membrane protein |
Tissue Location | Expressed by glutamatergic neurons (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
LPPR4 belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting.
References
Trimbuch, T., et al. Cell 138(6):1222-1235(2009)Vasan, R.S., et al. JAMA 302(2):168-178(2009)Brauer, A.U., et al. Nat. Neurosci. 6(6):572-578(2003)
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