|Other Names||TBC1 domain family member 3C, TBC1D3C, TBC1D3D|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).|
|Cellular Location||Cell membrane; Lipid-anchor. Note=Associated with lipid rafts.|
|Tissue Location||Expressed in pancreas, thymus and testis.|
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TBC1D3C represents one of atleast 8 paralogs of TBC1D3 gene found on chromosome 17. These paralogs appear to be differentially expressed in human tissues. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking.
Hodzic, D., et al. Genomics 88(6):731-736(2006)Paulding, C.A., et al. Proc. Natl. Acad. Sci. U.S.A. 100(5):2507-2511(2003)
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