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SLC26A11 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86WA9 |
|---|---|
| Other Accession | NP_775897 |
| Gene ID | 284129 |
|---|---|
| Other Names | Sodium-independent sulfate anion transporter, Solute carrier family 26 member 11, SLC26A11 (HGNC:14471) |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC26A11 (HGNC:14471) |
|---|---|
| Function | Sodium-independent anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport (By similarity). Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC) (PubMed:12626430). In the kidney, mediates chloride-bicarbonate exchange, facilitating V- ATPase-mediated acid secretion (By similarity). May function as a chloride channel, playing an important role in moderating chloride homeostasis and neuronal activity in the cerebellum (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:Q80ZD3}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q80ZD3}; Multi-pass membrane protein |
| Tissue Location | Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart |
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC26A11 encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid.
References
Sindic, A., et al. Curr. Opin. Nephrol. Hypertens. 16(5):484-490(2007)Soleimani, M., et al. Semin. Nephrol. 26(5):375-385(2006)Vincourt, J.B., et al. FASEB J. 17(8):890-892(2003)
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