|Other Names||Mitochondrial-processing peptidase subunit beta, Beta-MPP, P-52, PMPCB, MPPB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves presequences (transit peptides) from mitochondrial protein precursors.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
PMPCB is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.
Luczynski, W., et al. Neoplasma 56(5):428-434(2009)Schwer, B., et al. J. Cell Biol. 158(4):647-657(2002)Nagao, Y., et al. J. Biol. Chem. 275(44):34552-34556(2000)
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