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ORC1L Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q13415
Peptide ID 26377
Additional Information
Gene ID 4998
Other Names Origin recognition complex subunit 1, Replication control protein 1, ORC1, ORC1L, PARC1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORC1
Synonyms ORC1L, PARC1
Function Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing.


Hemerly, A.S., et al. Science 323(5915):789-793(2009)Tatsumi, Y., et al. Genes Cells 13(10):1045-1059(2008)Wu, C., et al. Proteomics 7(11):1775-1785(2007)

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$ 80.00
Cat# BP4995c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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