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TM119 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q4V9L6
Peptide ID 91208351
Additional Information
Other Names Transmembrane protein 119, Osteoblast induction factor, OBIF, TMEM119
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM119
Function Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q8R138} Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R138}
Tissue Location Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues EMBL; AY358389; AAQ88755.1; -; mRNA EMBL; AK075501; BAC11656.1; -; mRNA EMBL; BC096825; AAH96825.1; -; mRNA CCDS; CCDS9119.1; - RefSeq; NP_859075.2; NM_181724.2 RefSeq; XP_011536573.1; XM_011538271.2 UniGene; Hs.449718; - ProteinModelPortal; Q4V9L6; - iPTMnet; Q4V9L6; - PhosphoSitePlus; Q4V9L6; - BioMuta; TMEM119; - DMDM; 74754588; - MaxQB; Q4V9L6; - PaxDb; Q4V9L6; - PeptideAtlas; Q4V9L6; - PRIDE; Q4V9L6; - ProteomicsDB; 62285; - TopDownProteomics; Q4V9L6; - Ensembl; ENST00000392806; ENSP00000376553; ENSG00000183160 GeneID; 338773; - KEGG; hsa:338773; - UCSC; uc001tng.4; human CTD; 338773; - EuPathDB; HostDB:ENSG00000183160.8; - GeneCards; TMEM119; - HGNC; HGNC:27884; TMEM119 HPA; HPA051870; - HPA; HPA052650; - neXtProt; NX_Q4V9L6; - OpenTargets; ENSG00000183160; - PharmGKB; PA143485640; - eggNOG; ENOG410IVJ5; Eukaryota eggNOG; ENOG410YT3F; LUCA GeneTree; ENSGT00390000017134; - HOGENOM; HOG000060327; - HOVERGEN; HBG080787; - InParanoid; Q4V9L6; - OMA; QYVMLIA; - OrthoDB; EOG091G0JGF; - PhylomeDB; Q4V9L6; - TreeFam; TF336958; - ChiTaRS; TMEM119; human GenomeRNAi; 338773; - PRO; PR:Q4V9L6; - Proteomes; UP000005640; Chromosome 12 Bgee; ENSG00000183160; - CleanEx; HS_TMEM119; - ExpressionAtlas; Q4V9L6; baseline and differential Genevisible; Q4V9L6; HS GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0005886; C:plasma membrane; IDA:UniProtKB GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl GO; GO:1903012; P:positive regulation of bone development; ISS:UniProtKB GO; GO:0030501; P:positive regulation of bone mineralization; IDA:UniProtKB GO; GO:0045669; P:positive regulation of osteoblast differentiation; IDA:UniProtKB GO; GO:0033690; P:positive regulation of osteoblast proliferation; IDA:UniProtKB GO; GO:0048515; P:spermatid differentiation; ISS:UniProtKB GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB InterPro; IPR031453; TMEM119 PANTHER; PTHR28645; PTHR28645; 1 Pfam; PF15724; TMEM119; 1 1: Evidence at protein level; Biomineralization; Cell membrane; Complete proteome; Cytoplasm; Differentiation; Endoplasmic reticulum; Glycoprotein; Membrane; Osteogenesis; Phosphoprotein; Polymorphism; Reference proteome; Signal; Spermatogenesis; Transmembrane; Transmembrane helix SIGNAL 1 25 CHAIN 26 283 Transmembrane protein 119 /FTId=PRO_0000251220 TOPO_DOM 26 96 Extracellular. TRANSMEM 97 117 Helical. TOPO_DOM 118 283 Cytoplasmic. MOD_RES 272 272 Phosphoserine CARBOHYD 41 41 O-linked (GalNAc...) serine {ECO:0000250|UniProtKB:Q8R138} VARIANT 72 72 I -> T (in dbSNP:rs7975237) /FTId=VAR_027663 CONFLICT 262 262 E -> G (in Ref. 2; BAC11656) SEQUENCE 283 AA; 29203 MW; 8676B7A11C06B569 CRC64; MVSAAAPSLL ILLLLLLGSV PATDARSVPL KATFLEDVAG SGEAEGSSAS SPSLPPPWTP ALSPTSMGPQ PITLGGPSPP TNFLDGIVDF FRQYVMLIAV VGSLAFLLMF IVCAAVITRQ KQKASAYYPS SFPKKKYVDQ SDRAGGPRAF SEVPDRAPDS RPEEALDSSR QLQADILAAT QNLKSPTRAA LGGGDGARMV EGRGAEEEEK GSQEGDQEVQ GHGVPVETPE AQEEPCSGVL EGAVVAGEGQ GELEGSLLLA QEAQGPVGPP ESPCACSSVH PSV
Research Areas
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Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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$ 80.00
Cat# BP5003c
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