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TM119 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q4V9L6 |
|---|
| Gene ID | 338773 |
|---|---|
| Other Names | Transmembrane protein 119, Osteoblast induction factor, OBIF, TMEM119 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TMEM119 |
|---|---|
| Function | Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up- regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q8R138}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R138}. Secreted |
| Tissue Location | Expressed in brain microglia (at protein level) (PubMed:26250788). Detected in urine (at protein level) (PubMed:37453717). Elevated expression levels seen in the brain of patients with Alzheimer disease (PubMed:26250788). Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues (PubMed:26250788). |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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$ 277.78
Cat# BP5003c
Ordering Information
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