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AGTR2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P50052
Additional Information
Gene ID 186
Other Names Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2, AGTR2
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGTR2 {ECO:0000303|PubMed:7790004, ECO:0000312|HGNC:HGNC:338}
Function Receptor for angiotensin II, a vasoconstricting peptide (PubMed:8185599, PubMed:28379944, PubMed:29967536, PubMed:31899086). Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways (PubMed:28379944). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15123706).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P35374}; Multi-pass membrane protein
Tissue Location In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine
Research Areas
Citations (0)
citation

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Background

AGTR2 belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology.

References

Tousoulis, D., et al. Am. J. Hypertens. 23(3):237-242(2010)Li, H., et al. Mol. Cancer Ther. 8(12):3255-3265(2009)Ichiki, T., et al. Nature 377(6551):748-750(1995)

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$ 277.78
Cat# BP5007c
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