|Other Names||Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2, AGTR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine|
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AGTR2 belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology.
Tousoulis, D., et al. Am. J. Hypertens. 23(3):237-242(2010)Li, H., et al. Mol. Cancer Ther. 8(12):3255-3265(2009)Ichiki, T., et al. Nature 377(6551):748-750(1995)
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