AGTR2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P50052 |
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Gene ID | 186 |
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Other Names | Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2, AGTR2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AGTR2 {ECO:0000303|PubMed:7790004, ECO:0000312|HGNC:HGNC:338} |
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Function | Receptor for angiotensin II, a vasoconstricting peptide (PubMed:8185599, PubMed:28379944, PubMed:29967536, PubMed:31899086). Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways (PubMed:28379944). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15123706). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P35374}; Multi-pass membrane protein |
Tissue Location | In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine |
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Provided below are standard protocols that you may find useful for product applications.
Background
AGTR2 belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology.
References
Tousoulis, D., et al. Am. J. Hypertens. 23(3):237-242(2010)Li, H., et al. Mol. Cancer Ther. 8(12):3255-3265(2009)Ichiki, T., et al. Nature 377(6551):748-750(1995)
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