|Other Names||T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B71, B7, CD80, CD80, CD28LG, CD28LG1, LAB7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD28LG, CD28LG1, LAB7|
|Function||Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed on activated B-cells, macrophages and dendritic cells|
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Provided below are standard protocols that you may find useful for product applications.
CD80 is activation antigen B7-1 (formerly referred to as B7) provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 (MIM 186760) and CTLA4 (MIM 123890) ligands of T cells.
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)Segat, L., et al. J. Gastroenterol. Hepatol. 24(12):1840-1846(2009)
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