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FOLR2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P14207
Peptide ID 36102
Additional Information
Gene ID 2350
Other Names Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOLR2
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Cellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted
Tissue Location Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues
Research Areas
Citations (0)

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FOLR2 is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.


Puig-Kroger, A., et al. Cancer Res. 69(24):9395-9403(2009)Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)

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$ 80.00
Cat# BP5032a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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