GALP Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9UBC7 |
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Gene ID | 85569 |
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Other Names | Galanin-like peptide, GALP |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GALP |
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Function | [Isoform 1]: Hypothalamic neuropeptide which binds to the G- protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion. |
Cellular Location | Secreted. |
Tissue Location | Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
GALP encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction.
References
Schjeide, B.M., et al. Neurogenetics 10(1):19-25(2009)Lang, R., et al. Pharmacol. Ther. 115(2):177-207(2007)Santic, R., et al. Proc. Natl. Acad. Sci. U.S.A. 104(24):10217-10222(2007)
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