|Other Names||Keratin-associated protein 1-1, High sulfur keratin-associated protein 11, Keratin-associated protein 11, Keratin-associated protein 16, Keratin-associated protein 17, KRTAP1-1, B2A, KAP11, KAP16, KAP17, KRTAP11|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1|
|Function||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.|
|Tissue Location||Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone|
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KRTAP1-1 is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21.
Shimomura, Y., et al. J. Invest. Dermatol. 118(2):226-231(2002)Rogers, M.A., et al. J. Biol. Chem. 276(22):19440-19451(2001)
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