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MAGT1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H0U3 |
|---|
| Gene ID | 84061 |
|---|---|
| Other Names | Magnesium transporter protein 1, MagT1, Implantation-associated protein, IAP, MAGT1, IAG2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MAGT1 (HGNC:28880) |
|---|---|
| Synonyms | IAG2 |
| Function | Accessory component of the STT3B-containing form of the N- oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (PubMed:31831667). Involved in N- glycosylation of STT3B-dependent substrates (PubMed:31831667). Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase- independent functions in the STT3B-containing OST complex possibly involving substrate recognition. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitous. Expressed at very low levels in brain, lung and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
MAGT1 encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29.
References
Zhou, H., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15750-15755(2009)Molinari, F., et al. Am. J. Hum. Genet. 82(5):1150-1157(2008)Shibatani, T., et al. Biochemistry 44(16):5982-5992(2005)
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