|Other Names||Migration and invasion-inhibitory protein, IGFBP2-binding protein, Invasion-inhibitory protein 45, IIp45, MIIP, IIP45|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion.|
|Tissue Location||Ubiquitous. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells|
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Provided below are standard protocols that you may find useful for product applications.
MIIP inhibits glioma cells invasion and down-regulates adhesion-and motility-associated genes such as NFKB2 and ICAM1. MIIP exhibits opposing effects to IGFBP2 on cell invasion.
Wu, Y., et al. J. Biol. Chem. 285(6):3554-3560(2010)Song, F., et al. Cancer Res. 70(3):1024-1032(2010)Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
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