|Other Names||Transmembrane protein 127, TMEM127|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Qin, Y., et al. Nat. Genet. 42(3):229-233(2010)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Loftus, B.J., et al. Genomics 60(3):295-308(1999)
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