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XRCC6 Antibody (Center) Blocking peptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP5089c | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
XRCC6 Antibody (Center) Blocking peptide - Product info | |
| Primary Accession | P12956 |
| Other Accession | NP_001460.1 |
| Clone Names | 81205050 |
| Calculated MW | 69843 Da |
XRCC6 Antibody (Center) Blocking peptide - Additional info | |
| Gene ID 2547 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
XRCC6 Antibody (Center) Blocking peptide - Protein Information | |
| Name XRCC6 | |
| Synonyms G22P1 | |
| Function Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription | |
| Cellular Location Nucleus. Chromosome. | |
XRCC6 Antibody (Center) Blocking peptide - Related products
AP5089b: XRCC6 Antibody (C-term)
AP5089c: XRCC6 Antibody (Center)
AP6775a: Ku70 Antibody (N-term)
AP6775c: Ku70 Antibody (Center)
RI15763: XRCC6 predesign siRNA
LY10971a: XRCC6 Over-expression Lysate
BP5089b: XRCC6 Antibody (C-term) Blocking Peptide
BP5089c: XRCC6 Antibody (Center) Blocking peptide
BP6775a: Ku70 Antibody (N-term) Blocking Peptide
BP6775c: Ku70 Antibody (Center) Blocking Peptide
AT2136a: G22P1 Antibody (monoclonal) (M01)
XRCC6 Antibody (Center) Blocking peptide - Research Areas
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BACKGROUND
The p70/p80 autoantigen is a nuclear complex consisting oftwo subunits with molecular masses of approximately 70 and 80 kDa.The complex functions as a single-stranded DNA-dependentATP-dependent helicase. The complex may be involved in the repairof nonhomologous DNA ends such as that required for double-strandbreak repair, transposition, and V(D)J recombination. High levelsof autoantibodies to p70 and p80 have been found in some patientswith systemic lupus erythematosus.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Liu, Y., et al. Carcinogenesis 31(10):1762-1769(2010)Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)Pace, P., et al. Science 329(5988):219-223(2010)Sobczuk, A., et al. Pol J Pathol 61(1):27-31(2010)
