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REN Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00797 |
|---|
| Gene ID | 5972 |
|---|---|
| Other Names | Renin, Angiotensinogenase, REN |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | REN |
|---|---|
| Function | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Cellular Location | Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance.
References
Vangjeli, C., et al. Circ Cardiovasc Genet 3(1):53-59(2010)Wilke, R.A., et al. Pharmacogenomics 10(11):1789-1797(2009)Chen, S., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297 (5), R1526-R1531 (2009)
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