|Other Names||V-type proton ATPase 116 kDa subunit a isoform 2, V-ATPase 116 kDa isoform a2, Lysosomal H(+)-transporting ATPase V0 subunit a2, TJ6, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2, ATP6V0A2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endosome membrane. Note=In kidney proximal tubules, also detected in subapical vesicles.|
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Provided below are standard protocols that you may find useful for product applications.
ATP6V0A2 is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain.
Morava, E., et al. Eur. J. Hum. Genet. 17(9):1099-1110(2009)Guillard, M., et al. Biochim. Biophys. Acta 1792(9):903-914(2009)Hucthagowder, V., et al. Hum. Mol. Genet. 18(12):2149-2165(2009)
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