|Other Names||Rod outer segment membrane protein 1, ROSP1, Tetraspanin-23, Tspan-23, ROM1, TSPAN23|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Retina (photoreceptor). In rim region of ROS (rod outer segment) disks|
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ROM1 is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa.
Taylor, T.D., et al. Nature 440(7083):497-500(2006)Poetsch, A., et al. J. Biol. Chem. 276(51):48009-48016(2001)Wang, Q., et al. Ophthalmic Genet. 22(3):133-154(2001)
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