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ROM1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q03395 |
|---|
| Gene ID | 6094 |
|---|---|
| Other Names | Rod outer segment membrane protein 1, ROSP1, Tetraspanin-23, Tspan-23, ROM1, TSPAN23 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ROM1 |
|---|---|
| Synonyms | TSPAN23 |
| Function | Plays a role in rod outer segment (ROS) morphogenesis (By similarity). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By similarity). Plays a role in the organization of the ROS and maintenance of ROS disk diameter (By similarity). Involved in the maintenance of the retina outer nuclear layer (By similarity). |
| Cellular Location | Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:P32958, ECO:0000305|PubMed:1610568}; Multi-pass membrane protein. Photoreceptor outer segment membrane; Multi-pass membrane protein |
| Tissue Location | Retina photoreceptors (at protein level) (PubMed:1610568, PubMed:8504299). In rim region of ROS disks (PubMed:1610568). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ROM1 is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa.
References
Taylor, T.D., et al. Nature 440(7083):497-500(2006)Poetsch, A., et al. J. Biol. Chem. 276(51):48009-48016(2001)Wang, Q., et al. Ophthalmic Genet. 22(3):133-154(2001)
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