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TESC Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96BS2 |
|---|
| Gene ID | 54997 |
|---|---|
| Other Names | Calcineurin B homologous protein 3, Tescalcin, TSC, TESC, CHP3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TESC |
|---|---|
| Synonyms | CHP3 |
| Function | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. |
| Cellular Location | Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9JKL5} Note=Colocalizes with SLC9A1 at the plasma membrane |
| Tissue Location | Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation.
References
Bao, Y., et al. Gene Expr. Patterns 9(5):273-281(2009)Zaun, H.C., et al. J. Biol. Chem. 283(18):12456-12467(2008)Levay, K., et al. J. Clin. Invest. 117(9):2672-2683(2007)
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