|Other Names||MAGUK p55 subfamily member 4, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein, Discs large homolog 6, MPP4, ALS2CR5, DLG6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in retinal photoreceptors development.|
|Cellular Location||Cytoplasm. Note=Detected at the outer limiting membrane (OLM) and in the outer plexiform layer (OPL) of the retina. At the OLM, detected apical to the adherens junction (AJ)|
|Tissue Location||Expressed in the retina (at protein level). Highly expressed in the retina. Lower amounts are detected in brain, testis, ARPE-19, RPE/choroid and fetal eye. Isoform 5 is retina-specific.|
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MPP4 encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions.
Voss, M., et al. BMC Immunol. 10, 53 (2009) Kantardzhieva, A., et al. Invest. Ophthalmol. Vis. Sci. 46(6):2192-2201(2005)Stohr, H., et al. J. Comp. Neurol. 481(1):31-41(2005)
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