|Other Names||Ectonucleoside triphosphate diphosphohydrolase 8, E-NTPDase 8, NTPDase 8, NTPDase8, ENTPD8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
ENTPD8 is canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. It is ectonucleoside NTPDases catalyze the hydrolyzis of gamma-and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. ENTPD8 has activity toward ATP, ADP, UTP and UDP, but not toward AMP.
Munkonda, M.N., et al. Biochem. Pharmacol. 74(10):1524-1534(2007)Fausther, M., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 292 (3), G785-G795 (2007) Knowles, A.F., et al. Biochemistry 45(23):7323-7333(2006)
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