|Other Names||Ataxin-2-like protein, Ataxin-2 domain protein, Ataxin-2-related protein, ATXN2L, A2D, A2LG, A2LP, A2RP|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||A2D, A2LG, A2LP, A2RP|
|Function||Involved in the regulation of stress granule and P-body formation.|
|Cellular Location||Membrane; Peripheral membrane protein Cytoplasm. Nucleus speckle. Cytoplasmic granule. Note=Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791) Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791)|
|Tissue Location||Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells|
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ATXN2L encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders.
Imielinski, M., et al. Nat. Genet. 41(12):1335-1340(2009)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Nonhoff, U., et al. Mol. Biol. Cell 18(4):1385-1396(2007)
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