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C5orf30 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96GV9 |
|---|
| Gene ID | 90355 |
|---|---|
| Other Names | UNC119-binding protein C5orf30, C5orf30 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MACIR (HGNC:25052) |
|---|---|
| Synonyms | C5orf30 |
| Function | Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages (PubMed:30659109). The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis (PubMed:30659109). May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B (PubMed:22085962). May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (PubMed:22085962). |
| Cellular Location | Cytoplasm. Cell projection, cilium. Note=Localizes to the transition zone and proximal cilium in addition to being found throughout the cytoplasm. |
| Tissue Location | High expression in normal macrophages, monocytes, and cultured rheumatoid arthritis synovial fibroblasts (RASFs), with lower expression in B- and T-cells, and little to no expression in other tissues and cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein has not been specifically defined.
References
Ota, T., et al. Nat. Genet. 36(1):40-45(2004)
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