|Other Names||DNA-directed RNA polymerase I subunit RPA43, Twist neighbor protein, TWISTNB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.|
|Cellular Location||Nucleus, nucleolus.|
|Tissue Location||Widely expressed. Expressed in all fetal and adult tissues tested, with highest expression in fetal lung, liver, and kidney, and low expression in all adult tissues|
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Provided below are standard protocols that you may find useful for product applications.
RPA43 is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.
Olsen, J.V., et al. Cell 127(3):635-648(2006)Yuan, X., et al. EMBO Rep. 3(11):1082-1087(2002)Kosan, C., et al. Cytogenet. Genome Res. 97 (3-4), 167-170 (2002)
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