ZFN2B Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8WV99 |
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Other Accession | NP_620157.1 |
Clone Names | 91208127 |
Gene ID | 130617 |
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Other Names | AN1-type zinc finger protein 2B, Arsenite-inducible RNA-associated protein-like protein, AIRAP-like protein, ZFAND2B, AIRAPL |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ZFAND2B (HGNC:25206) |
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Function | Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91X58}; Lipid-anchor {ECO:0000250|UniProtKB:Q91X58} |
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Provided below are standard protocols that you may find useful for product applications.
References
Hassan, W.M., et al. Hum. Mol. Genet. 18(15):2739-2747(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Yun, C., et al. Proc. Natl. Acad. Sci. U.S.A. 105(19):7094-7099(2008)
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