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ZFN2B Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8WV99
Other Accession NP_620157.1
Clone Names 91208127
Additional Information
Gene ID 130617
Other Names AN1-type zinc finger protein 2B, Arsenite-inducible RNA-associated protein-like protein, AIRAP-like protein, ZFAND2B, AIRAPL
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZFAND2B (HGNC:25206)
Function Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91X58}; Lipid-anchor {ECO:0000250|UniProtKB:Q91X58}
Research Areas
Citations (0)
citation

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References

Hassan, W.M., et al. Hum. Mol. Genet. 18(15):2739-2747(2009)Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)Yun, C., et al. Proc. Natl. Acad. Sci. U.S.A. 105(19):7094-7099(2008)

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$ 277.78
Cat# BP5304a
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