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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   GNE Antibody (C-term) Blocking peptide   

GNE Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9Y223
Other Accession NP_005467.1
Clone Names 91013034
Peptide ID 91013034
Additional Information
Gene ID 10020
Other Names Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase/ManAc kinase, UDP-N-acetylglucosamine 2-epimerase (hydrolyzing), UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, N-acetylmannosamine kinase, ManAc kinase, GNE, GLCNE
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GNE
Synonyms GLCNE
Function Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development (By similarity). Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
Cellular Location Cytoplasm.
Tissue Location Highest expression in liver and placenta. Also found in heart, brain, lung, kidney, skeletal muscle and pancreas Isoform 1 is expressed in heart, brain, kidney, liver, placenta, lung, spleen, pancreas, skeletal muscle and colon. Isoform 2 is expressed mainly in placenta, but also in brain, kidney, liver, lung, pancreas and colon. Isoform 3 is expressed at low level in kidney, liver, placenta and colon.
Research Areas
Citations (0)

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GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.


Reinke, S.O., et al. Glycoconj. J. 26(4):415-422(2009)Tong, Y., et al. PLoS ONE 4 (10), E7165 (2009) Klootwijk, R.D., et al. FASEB J. 22(11):3846-3852(2008)

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$ 80.00
Cat# BP5318b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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