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STAMBPL1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96FJ0 |
|---|---|
| Other Accession | NP_065850.1 |
| Clone Names | 91102163 |
| Gene ID | 57559 |
|---|---|
| Other Names | AMSH-like protease, AMSH-LP, 3419-, STAM-binding protein-like 1, STAMBPL1, AMSHLP, KIAA1373 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | STAMBPL1 {ECO:0000303|PubMed:35114100, ECO:0000312|HGNC:HGNC:24105} |
|---|---|
| Function | Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys- 63'-linked deubiquitination of SESN2, thereby inhibiting SESN2- interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443). |
| Tissue Location | Ubiquitously expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
STAMBPL1 is zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.
References
Reyes-Ibarra, A.P., et al. Mol. Endocrinol. 21(6):1394-1407(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Nakamura, M., et al. Genes Cells 11(6):593-606(2006)
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