|Other Names||CTP synthase 1, CTP synthetase 1, UTP--ammonia ligase 1, CTPS1 (HGNC:2519)|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP- dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types.
Higgins, M.J., et al. Nucleosides Nucleotides Nucleic Acids 27(6):850-857(2008)Higgins, M.J., et al. J. Biol. Chem. 282(40):29493-29503(2007)Chang, Y.F., et al. J. Biol. Chem. 282(24):17613-17622(2007)
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