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CTPS Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P17812
Other Accession NP_001896.2
Clone Names 90921050
Additional Information
Gene ID 1503
Other Names CTP synthase 1, CTP synthetase 1, UTP--ammonia ligase 1, CTPS1 (HGNC:2519)
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTPS1 (HGNC:2519)
Function This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
Cellular Location Cytoplasm, cytosol. Note=Mainly cytosolic but when active detected in long filamentous structures (PubMed:25223282). Co-localizes with TNK2 in the cytosolic filaments (By similarity). {ECO:0000250|UniProtKB:P70698, ECO:0000269|PubMed:25223282}
Tissue Location Widely expressed..
Research Areas
Citations (0)
citation

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Background

The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types.

References

Higgins, M.J., et al. Nucleosides Nucleotides Nucleic Acids 27(6):850-857(2008)Higgins, M.J., et al. J. Biol. Chem. 282(40):29493-29503(2007)Chang, Y.F., et al. J. Biol. Chem. 282(24):17613-17622(2007)

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$ 277.78
Cat# BP5337b
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