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SMAD6 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O43541
Other Accession NP_005576.3
Clone Names 91019084
Peptide ID 91019084
Additional Information
Gene ID 4091
Other Names Mothers against decapentaplegic homolog 6, MAD homolog 6, Mothers against DPP homolog 6, SMAD family member 6, SMAD 6, Smad6, hSMAD6, SMAD6, MADH6
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMAD6
Synonyms MADH6
Function Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Cellular Location Nucleus.
Tissue Location Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue
Research Areas
Citations (0)

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SMAD6 belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling.


Tseng, Z.H., et al. Heart Rhythm 6(12):1745-1750(2009)Shintani, M., et al. J. Med. Genet. 46(5):331-337(2009)Yu, H., et al. Acta Derm. Venereol. 89(4):351-356(2009)

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$ 80.00
Cat# BP5344c
(40 western blots)
Availability: In Stock
Bulk Size
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