|Other Names||GC-rich sequence DNA-binding factor 2, GC-rich sequence DNA-binding factor, Transcription factor 9, TCF-9, GCFC2, C2orf3, GCF, TCF9|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C2orf3, GCF, TCF9|
|Function||Factor that represses transcription. It binds to the GC- rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, nucleolus|
|Tissue Location||Widely expressed in tissues and cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene.
Wu, C., et al. Proteomics 7(11):1775-1785(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Anthoni, H., et al. Hum. Mol. Genet. 16(6):667-677(2007)
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