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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   HNRPDL Antibody (Center) Blocking peptide   

HNRPDL Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession O14979
Other Accession NP_112740.1
Clone Names 91102105
Peptide ID 91102105
Additional Information
Gene ID 9987
Other Names Heterogeneous nuclear ribonucleoprotein D-like, hnRNP D-like, hnRNP DL, AU-rich element RNA-binding factor, JKT41-binding protein, Protein laAUF1, HNRNPDL, HNRPDL, JKTBP
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HNRNPDL
Synonyms HNRPDL, JKTBP
Function Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner
Tissue Location Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells.
Research Areas
Citations (0)

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Background

HNRPDL belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein has two RRM domains that bind to RNAs.

References

Walker, L.C., et al. Breast Cancer Res. Treat. 112(2):229-236(2008)Wu, Y.Y., et al. Cell Biochem. Funct. 26(4):467-477(2008)Reboll, M.R., et al. RNA 13(8):1328-1340(2007)

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$ 80.00
Cat# BP5352c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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