|Other Accession||P52927, NP_003475.1, NP_003474.1|
|Other Names||High mobility group protein HMGI-C, High mobility group AT-hook protein 2, HMGA2, HMGIC|
|Target/Specificity||The synthetic peptide sequence is selected from aa 79-92 of HUMAN HMGA2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes.|
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This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Pillas, D., et al. PLoS Genet. 6 (2), E1000856 (2010) :
Yang, T.L., et al. Ann. Hum. Genet. 74(1):11-16(2010)
Wei, J.J., et al. Am. J. Surg. Pathol. 34(1):18-26(2010)
Tay, Y., et al. Stem Cell Rev 5(4):328-333(2009)
Schwanbeck, R., et al. J. Biol. Chem. 275(3):1793-1801(2000)
Chau, K.Y., et al. Nucleic Acids Res. 23(21):4262-4266(1995)
Schoenmakers, E.F., et al. Nat. Genet. 10(4):436-444(1995)
Ashar, H.R., et al. Cell 82(1):57-65(1995)
Schoenmakers, E.F., et al. Genes Chromosomes Cancer 11(2):106-118(1994)
Manfioletti, G., et al. Nucleic Acids Res. 19(24):6793-6797(1991)
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