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B3GALNT1 Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession O75752
Other Accession Q864U6, NP_001033717.1, NP_149358.1, NP_149357.1, NP_149359.1, NP_003772.1
Additional Information
Gene ID 8706
Other Names UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 1, Beta-1, 3-GalNAc-T1, Beta-1, 3-galactosyltransferase 3, Beta-1, 3-GalTase 3, Beta3Gal-T3, Beta3GalT3, b3Gal-T3, Beta-3-Gx-T3, Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase, Globoside synthase, UDP-N-acetylgalactosamine:globotriaosylceramide beta-1, 3-N-acetylgalactosaminyltransferase, B3GALNT1, B3GALT3
Target/Specificity The synthetic peptide sequence is selected from aa 53-64 of HUMAN B3GALNT1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name B3GALNT1
Synonyms B3GALT3
Function Transfers N-acetylgalactosamine onto globotriaosylceramide.
Cellular Location Golgi apparatus membrane; Single-pass type II membrane protein
Tissue Location Higher expression in heart and brain, and to a lesser extent in lung, placenta, kidney and testis. Lower expression in liver, spleen and stomach. No expression in skeletal muscle.
Research Areas
Citations (0)

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Background

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. Multiple transcript variants that are alternatively spliced in the 5' UTR have been described; they all encode the same protein. [provided by RefSeq].

References

Masui, S., et al. Int. J. Legal Med. 123(3):205-211(2009)
Hellberg, A., et al. Br. J. Haematol. 125(4):528-536(2004)
Hellberg, A., et al. J. Biol. Chem. 277(33):29455-29459(2002)
Okajima, T., et al. J. Biol. Chem. 275(51):40498-40503(2000)
Amado, M., et al. Biochim. Biophys. Acta 1473(1):35-53(1999)
Amado, M., et al. J. Biol. Chem. 273(21):12770-12778(1998)
Almeida, R., et al. J. Biol. Chem. 272(51):31979-31991(1997)
Taniguchi, N., et al. J. Biol. Chem. 259(9):5637-5642(1984)

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$ 80.00
$ 99.00
Cat# BP5364a
Size:
Quantity:
(40 western blots)
Availability: 2 weeks
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