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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   SIKE Blocking Peptide (C-term)   

SIKE Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession Q9BRV8
Other Accession Q5FWT9, Q0VCF3, NP_001095866.1, NP_079349.2
Additional Information
Gene ID 80143
Other Names Suppressor of IKBKE 1, Suppressor of IKK-epsilon, SIKE1, SIKE
Target/Specificity The synthetic peptide sequence is selected from aa 169-182 of HUMAN SIKE1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIKE1
Synonyms SIKE
Function Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
Cellular Location Cytoplasm.
Tissue Location Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).
Research Areas
Citations (0)

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SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).


Goudreault, M., et al. Mol. Cell Proteomics 8(1):157-171(2009)
Huang, J., et al. EMBO J. 24(23):4018-4028(2005)

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$ 80.00
$ 99.00
Cat# BP5375b
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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