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PYHIN1 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6K0P9 |
|---|---|
| Other Accession | Q16666, NP_945146.1, NP_945148.1 |
| Gene ID | 149628 |
|---|---|
| Other Names | Pyrin and HIN domain-containing protein 1, Interferon-inducible protein X, PYHIN1, IFIX |
| Target/Specificity | The synthetic peptide sequence is selected from aa 41-55 of HUMAN PYHIN1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PYHIN1 |
|---|---|
| Synonyms | IFIX |
| Function | Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. |
| Cellular Location | [Isoform 1]: Nucleus, nucleoplasm. [Isoform 5]: Nucleus. Nucleus speckle. |
| Tissue Location | Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PYHIN1 belongs to the HIN200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-terminal ends. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis (Ding et al., 2006 [PubMed 16479015]).
References
Yamaguchi, H., et al. Mol. Carcinog. 47(10):739-743(2008)
Ding, Y., et al. Mol. Cell. Biol. 26(5):1979-1996(2006)
Ding, Y., et al. Oncogene 23(26):4556-4566(2004)
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