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SDHAF1 Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession A6NFY7
Other Accession B0K036, Q3U276, A8PU71, NP_001036096.1
Additional Information
Gene ID 644096
Other Names Succinate dehydrogenase assembly factor 1, mitochondrial, SDH assembly factor 1, SDHAF1, LYR motif-containing protein 8, SDHF1
Target/Specificity The synthetic peptide sequence is selected from aa 49-62 of HUMAN SDHF1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SDHF1
Function Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.
Cellular Location Mitochondrion matrix
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).


Ghezzi, D., et al. Nat. Genet. (2009) In press :
Hoffmann, T.W., et al. Transplant. Proc. 41(2):654-656(2009)

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$ 80.00
$ 99.00
Cat# BP5392C
(40 western blots)
Availability: 2 weeks
Bulk Size
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